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| H | CF América | - | UANL Tigres | 0:4 (0:2) | ||
| R | UANL Tigres | - | CF América | 2:0 (0:0) | ||
| H: 07.05.2021 17:00 | R: 11.05.2021 03:00 | Sieger: UANL Tigres | ||||
| H | Pumas UNAM | - | CF Monterrey | 1:2 (0:2) | ||
| R | CF Monterrey | - | Pumas UNAM | 2:1 (0:1) | ||
| H: 07.05.2021 19:00 | R: 11.05.2021 05:00 | Sieger: CF Monterrey | ||||
| H | Deportivo Toluca | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| R | Deportivo Guadalajara | - | Deportivo Toluca | 3:0 (0:0) | ||
| H: 07.05.2021 23:00 | R: 11.05.2021 01:00 | Sieger: Deportivo Guadalajara | ||||
| H | CF Pachuca | - | Atlas Guadalajara | 0:2 (0:1) | ||
| R | Atlas Guadalajara | - | CF Pachuca | 3:1 (1:0) | ||
| H: 08.05.2021 01:30 | R: 10.05.2021 23:00 | Sieger: Atlas Guadalajara | ||||
