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| 15.10.2021 | 17:00 | FK Sūduva | - | FK Riteriai | 1:1 (0:0) | |
| 16.10.2021 | 12:00 | Hegelmann Litauen | - | Kauno Žalgiris | 1:2 (0:2) | |
| 14:00 | FC Džiugas | - | DFK Dainava | 1:1 (1:1) | ||
| 17.10.2021 | 14:00 | FK Banga Gargždai | - | FK Panevėžys | 2:1 (2:1) | |
| 18.10.2021 | 16:00 | FK Žalgiris | - | FK Nevėžis | 3:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Žalgiris | 32 | 20 | 9 | 3 | 69:25 | 44 | 69 |
| 2 |
|
FK Sūduva | 32 | 19 | 7 | 6 | 57:29 | 28 | 64 |
| 3 |
|
Kauno Žalgiris | 32 | 16 | 8 | 8 | 48:37 | 11 | 56 |
| 4 |
|
FK Panevėžys | 32 | 14 | 10 | 8 | 46:35 | 11 | 52 |
| 5 |
|
Hegelmann Litauen | 32 | 13 | 9 | 10 | 48:33 | 15 | 48 |
| 6 |
|
FK Riteriai | 32 | 9 | 14 | 9 | 42:35 | 7 | 41 |
| 7 |
|
FC Džiugas | 32 | 8 | 11 | 13 | 41:47 | -6 | 35 |
| 8 |
|
DFK Dainava | 32 | 8 | 10 | 14 | 37:51 | -14 | 31 |
| 9 |
|
FK Banga Gargždai | 32 | 8 | 4 | 20 | 35:69 | -34 | 28 |
| 10 |
|
FK Nevėžis | 32 | 2 | 4 | 26 | 14:76 | -62 | 10 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# 3 Punkte Abzug für DFK Dainava wegen Verstoßes gegen die Lizenzauflagen. |
