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| 17.09.2021 | 17:00 | DFK Dainava | - | FK Sūduva | 1:2 (0:2) | |
| 18.09.2021 | 14:00 | FC Džiugas | - | FK Žalgiris | 2:1 (1:0) | |
| 16:00 | FK Banga Gargždai | - | Kauno Žalgiris | 2:3 (2:1) | ||
| 19.09.2021 | 12:00 | Hegelmann Litauen | - | FK Panevėžys | 1:0 (0:0) | |
| 14:00 | FK Riteriai | - | FK Nevėžis | 4:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Žalgiris | 27 | 18 | 6 | 3 | 59:20 | 39 | 60 |
| 2 |
|
FK Sūduva | 27 | 17 | 4 | 6 | 47:25 | 22 | 55 |
| 3 |
|
Kauno Žalgiris | 27 | 14 | 7 | 6 | 44:30 | 14 | 49 |
| 4 |
|
FK Panevėžys | 27 | 13 | 7 | 7 | 39:31 | 8 | 46 |
| 5 |
|
Hegelmann Litauen | 27 | 11 | 7 | 9 | 39:28 | 11 | 40 |
| 6 |
|
FK Riteriai | 27 | 8 | 11 | 8 | 36:29 | 7 | 35 |
| 7 |
|
FC Džiugas | 27 | 8 | 7 | 12 | 35:40 | -5 | 31 |
| 8 |
|
FK Banga Gargždai | 27 | 7 | 3 | 17 | 31:56 | -25 | 24 |
| 9 |
|
DFK Dainava | 27 | 6 | 7 | 14 | 32:48 | -16 | 22 |
| 10 |
|
FK Nevėžis | 27 | 2 | 3 | 22 | 12:67 | -55 | 9 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# 3 Punkte Abzug für DFK Dainava wegen Verstoßes gegen die Lizenzauflagen. |
