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| 22.05.2022 | 14:30 | Afragolese | - | Muravera | 2:1 | |
| 14:30 | Lanusei Calcio | - | Ostia Mare | 2:2 | ||
| 15:00 | FC Aprilia | - | ASD Carbonia Calcio | 4:1 | ||
| 15:00 | Formia | - | SEF Torres 1903 | 0:0 | ||
| 15:00 | Sassari Latte Dolce | - | Team Nuova Florida | 2:1 | ||
| 16:00 | Atletico Uri | - | Arzachena | 1:3 | ||
| 16:00 | Giugliano | - | Cassino Calcio 1924 | 2:0 | ||
| 16:00 | Gladiator | - | ASD Vis Artena | 0:1 | ||
| 16:00 | Real Monterotondo Scalo | - | CynthiAlbalonga | 2:2 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Giugliano | 33 | 24 | 3 | 6 | 61:18 | 43 | 75 |
| 2 |
|
Team Nuova Florida | 33 | 19 | 6 | 8 | 53:35 | 18 | 63 |
| 3 |
|
SEF Torres 1903 | 33 | 17 | 12 | 4 | 52:18 | 34 | 63 |
| 4 |
|
Arzachena | 33 | 18 | 7 | 8 | 50:36 | 14 | 61 |
| 5 |
|
Afragolese | 33 | 17 | 7 | 9 | 56:41 | 15 | 58 |
| 6 |
|
CynthiAlbalonga | 33 | 15 | 7 | 11 | 56:43 | 13 | 52 |
| 7 |
|
FC Aprilia | 33 | 15 | 6 | 12 | 44:37 | 7 | 51 |
| 8 |
|
Ostia Mare | 33 | 13 | 8 | 12 | 43:35 | 8 | 47 |
| 9 |
|
ASD Vis Artena | 33 | 13 | 7 | 13 | 44:45 | -1 | 46 |
| 10 |
|
Muravera | 33 | 14 | 4 | 15 | 51:57 | -6 | 46 |
| 11 |
|
Gladiator | 33 | 12 | 8 | 13 | 48:49 | -1 | 44 |
| 12 |
|
Real Monterotondo Scalo | 33 | 10 | 6 | 17 | 45:59 | -14 | 36 |
| 13 |
|
Cassino Calcio 1924 | 33 | 8 | 11 | 14 | 35:49 | -14 | 35 |
| 14 |
|
Atletico Uri | 33 | 9 | 8 | 16 | 32:52 | -20 | 35 |
| 15 |
|
Lanusei Calcio | 33 | 6 | 10 | 17 | 32:52 | -20 | 28 |
| 16 |
|
Formia | 33 | 7 | 7 | 19 | 32:63 | -31 | 28 |
| 17 |
|
Sassari Latte Dolce | 33 | 6 | 9 | 18 | 28:46 | -18 | 27 |
| 18 |
|
ASD Carbonia Calcio | 33 | 5 | 12 | 16 | 35:62 | -27 | 26 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
