 |
 |
|
|
| 18.12.2021 | 18:30 | Panetolikos | - | Atromitos | 2:1 (1:0) | |
| 19.12.2021 | 14:00 | Olympiakos Piraeus | - | Lamia | 1:0 (1:0) | |
| 18:30 | Panathinaikos | - | PAS Giannina | 2:0 (0:0) | ||
| 18:30 | PAOK Saloniki | - | Asteras Tripolis | 3:2 (1:1) | ||
| 20.12.2021 | 18:30 | AEK Athen | - | OFI Heraklion | 1:2 (1:1) | |
| 18:30 | Aris Saloniki | - | Ionikos Nikea | 1:0 (0:0) | ||
| 19.01.2022 | 14:00 | Volos NFC | - | Apollon Smyrnis | 1:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Olympiakos Piraeus | 15 | 13 | 2 | 0 | 28:9 | 19 | 41 |
| 2 |
|
AEK Athen | 15 | 9 | 3 | 3 | 27:16 | 11 | 30 |
| 3 |
|
PAOK Saloniki | 15 | 9 | 1 | 5 | 31:20 | 11 | 28 |
| 4 |
|
Aris Saloniki | 15 | 8 | 3 | 4 | 17:13 | 4 | 27 |
| 5 |
|
Panathinaikos | 15 | 8 | 2 | 5 | 27:11 | 16 | 26 |
| 6 |
|
OFI Heraklion | 15 | 6 | 7 | 2 | 20:14 | 6 | 25 |
| 7 |
|
PAS Giannina | 15 | 6 | 4 | 5 | 19:16 | 3 | 22 |
| 8 |
|
Volos NFC | 15 | 5 | 3 | 7 | 25:29 | -4 | 18 |
| 9 |
|
Asteras Tripolis | 15 | 4 | 5 | 6 | 15:15 | 0 | 17 |
| 10 |
|
Panetolikos | 15 | 4 | 3 | 8 | 16:27 | -11 | 15 |
| 11 |
|
Ionikos Nikea | 15 | 3 | 5 | 7 | 13:20 | -7 | 14 |
| 12 |
|
Lamia | 15 | 2 | 5 | 8 | 13:20 | -7 | 11 |
| 13 |
|
Atromitos | 15 | 2 | 3 | 10 | 14:32 | -18 | 9 |
| 14 |
|
Apollon Smyrnis | 15 | 1 | 4 | 10 | 7:30 | -23 | 7 |
| Playoffs | |
| Relegation |
