 |
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| 12.04.2022 | 14:00 | FC Utrecht | - | ADO Den Haag | 3:1 | |
| 20:30 | Legia Warszawa | - | Dinamo Kiev | 1:3 | ||
| 14.04.2022 | 13:00 | PEC Zwolle | - | FC Twente | 1:1 (1:1) | |
| 14:00 | Go Ahead Eagles | - | FC Utrecht | 0:3 (0:2) | ||
| 16:00 | Galatasaray | - | Dinamo Kiev | 1:3 (0:2) | ||
| 19:30 | Lechia Gdańsk | - | Shakhtar Donetsk | 2:3 (1:1) | ||
| 15.04.2022 | 12:30 | NEC Nijmegen | - | sc Heerenveen | 1:1 |
