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| 01.05.2022 | 11:00 | Bayern München II | - | SV Meppen | 0:2 Wert. | |
| 11:00 | SV Henstedt-Ulzburg | - | 1. FC Nürnberg | 3:1 (1:1) | ||
| 11:00 | RB Leipzig | - | FC Ingolstadt 04 | 4:3 (1:2) | ||
| 11:00 | MSV Duisburg | - | SV 07 Elversberg | 6:1 (2:1) | ||
| 11:00 | VfL Wolfsburg II | - | Borussia Bocholt | 1:0 (1:0) | ||
| 14:00 | Eintracht Frankfurt II | - | FSV Gütersloh 2009 | 2:0 (1:0) | ||
| 14:00 | 1899 Hoffenheim II | - | SG 99 Andernach | 0:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 22 | 16 | 3 | 3 | 54:16 | 38 | 51 |
| 2 |
|
MSV Duisburg | 22 | 15 | 3 | 4 | 47:23 | 24 | 48 |
| 3 |
|
RB Leipzig | 22 | 14 | 2 | 6 | 58:37 | 21 | 44 |
| 4 |
|
SG 99 Andernach | 22 | 12 | 4 | 6 | 48:27 | 21 | 40 |
| 5 |
|
1. FC Nürnberg | 22 | 13 | 1 | 8 | 42:33 | 9 | 40 |
| 6 |
|
Eintracht Frankfurt II | 22 | 10 | 6 | 6 | 42:31 | 11 | 36 |
| 7 |
|
Bayern München II | 22 | 10 | 3 | 9 | 33:38 | -5 | 33 |
| 8 |
|
FSV Gütersloh 2009 | 22 | 8 | 4 | 10 | 38:36 | 2 | 28 |
| 9 |
|
1899 Hoffenheim II | 22 | 6 | 7 | 9 | 23:32 | -9 | 25 |
| 10 |
|
FC Ingolstadt 04 | 22 | 7 | 3 | 12 | 48:47 | 1 | 24 |
| 11 |
|
VfL Wolfsburg II | 22 | 5 | 5 | 12 | 16:35 | -19 | 20 |
| 12 |
|
SV 07 Elversberg | 22 | 5 | 4 | 13 | 20:49 | -29 | 19 |
| 13 |
|
SV Henstedt-Ulzburg | 22 | 5 | 3 | 14 | 32:63 | -31 | 18 |
| 14 |
|
Borussia Bocholt | 22 | 3 | 2 | 17 | 21:55 | -34 | 11 |
| Aufstieg | |
| Abstieg |
