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| 21.05.2022 | 18:00 | Angoulême CFC | - | Moulins Yzeure Foot | 0:0 (0:0) | |
| 18:00 | Andrézieux-Bouthéon FC | - | Le Puy Foot 43 | 0:1 (0:1) | ||
| 18:00 | Canet Roussillon | - | AS Béziers | 4:1 (1:0) | ||
| 18:00 | FC Chamalières | - | Angers SCO II | 1:0 (1:0) | ||
| 18:00 | FC Nantes (CFA) | - | Stade Montois | 2:2 (1:1) | ||
| 18:00 | Montpellier HSC (CFA) | - | Vendée Les Herbiers | 1:0 (1:0) | ||
| 18:00 | Trélissac FC | - | Bergerac Foot | 0:4 (0:1) | ||
| 18:00 | US Colomiers | - | Bourges Foot 18 | 1:4 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Le Puy Foot 43 | 29 | 17 | 7 | 5 | 38:16 | 22 | 58 |
| 2 |
|
Bergerac Foot | 29 | 16 | 9 | 4 | 36:15 | 21 | 57 |
| 3 |
|
Bourges Foot 18 | 29 | 16 | 5 | 8 | 44:24 | 20 | 53 |
| 4 |
|
Angoulême CFC | 29 | 13 | 10 | 6 | 32:22 | 10 | 49 |
| 5 |
|
Andrézieux-Bouthéon FC | 29 | 14 | 6 | 9 | 39:28 | 11 | 48 |
| 6 |
|
AS Béziers | 29 | 12 | 8 | 9 | 42:35 | 7 | 44 |
| 7 |
|
Moulins Yzeure Foot | 29 | 10 | 11 | 8 | 29:27 | 2 | 41 |
| 8 |
|
Canet Roussillon | 29 | 14 | 5 | 10 | 33:34 | -1 | 36 |
| 9 |
|
Vendée Les Herbiers | 29 | 9 | 9 | 11 | 30:33 | -3 | 36 |
| 10 |
|
Trélissac FC | 29 | 9 | 8 | 12 | 26:30 | -4 | 35 |
| 11 |
|
FC Nantes (CFA) | 29 | 8 | 10 | 11 | 32:35 | -3 | 34 |
| 12 |
|
Angers SCO II | 29 | 7 | 12 | 10 | 25:28 | -3 | 33 |
| 13 |
|
FC Chamalières | 29 | 8 | 7 | 14 | 29:40 | -11 | 31 |
| 14 |
|
Montpellier HSC (CFA) | 29 | 8 | 6 | 15 | 32:42 | -10 | 30 |
| 15 |
|
US Colomiers | 29 | 6 | 9 | 14 | 29:44 | -15 | 27 |
| 16 |
|
Stade Montois | 29 | 1 | 6 | 22 | 22:65 | -43 | 9 |
| Aufstieg | |
| Abstieg |
