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| 04.03.2022 | 20:00 | Angoulême CFC | - | Vendée Les Herbiers | 1:0 (0:0) | |
| 05.03.2022 | 16:00 | FC Nantes (CFA) | - | FC Chamalières | 2:1 (2:0) | |
| 17:00 | Trélissac FC | - | Angers SCO II | 1:1 (1:0) | ||
| 18:00 | AS Béziers | - | Bourges Foot 18 | 1:2 (0:1) | ||
| 18:00 | Canet Roussillon | - | Montpellier HSC (CFA) | 0:1 (0:0) | ||
| 18:00 | US Colomiers | - | Andrézieux-Bouthéon FC | 3:3 (2:1) | ||
| 18:30 | Moulins Yzeure Foot | - | Le Puy Foot 43 | 1:2 (1:0) | ||
| 18:30 | Stade Montois | - | Bergerac Foot | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Angoulême CFC | 20 | 11 | 6 | 3 | 27:15 | 12 | 39 |
| 2 |
|
Bergerac Foot | 20 | 10 | 8 | 2 | 23:10 | 13 | 38 |
| 3 |
|
Bourges Foot 18 | 20 | 10 | 4 | 6 | 29:18 | 11 | 34 |
| 4 |
|
Le Puy Foot 43 | 20 | 9 | 6 | 5 | 25:14 | 11 | 33 |
| 5 |
|
Andrézieux-Bouthéon FC | 20 | 9 | 5 | 6 | 26:19 | 7 | 32 |
| 6 |
|
Moulins Yzeure Foot | 20 | 8 | 8 | 4 | 21:16 | 5 | 32 |
| 7 |
|
FC Nantes (CFA) | 20 | 7 | 8 | 5 | 25:20 | 5 | 29 |
| 8 |
|
AS Béziers | 20 | 8 | 5 | 7 | 26:22 | 4 | 29 |
| 9 |
|
Trélissac FC | 20 | 6 | 6 | 8 | 17:18 | -1 | 24 |
| 10 |
|
Vendée Les Herbiers | 20 | 6 | 6 | 8 | 23:27 | -4 | 24 |
| 11 |
|
Angers SCO II | 20 | 5 | 8 | 7 | 20:21 | -1 | 23 |
| 12 |
|
FC Chamalières | 20 | 6 | 4 | 10 | 24:29 | -5 | 22 |
| 13 |
|
Canet Roussillon | 20 | 9 | 4 | 7 | 18:23 | -5 | 20 |
| 14 |
|
US Colomiers | 20 | 4 | 8 | 8 | 19:27 | -8 | 20 |
| 15 |
|
Montpellier HSC (CFA) | 20 | 5 | 4 | 11 | 19:29 | -10 | 19 |
| 16 |
|
Stade Montois | 20 | 1 | 2 | 17 | 14:48 | -34 | 5 |
| Aufstieg | |
| Abstieg |
