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| H | FC Martigues | - | SÉC Bastia | 3:0 | ||
| R | SÉC Bastia | - | FC Martigues | 5:0 | ||
| H: 08.05.1981 | R: 19.05.1981 | Sieger: SÉC Bastia | ||||
| H | RC Lens | - | Lille OSC | 3:1 | ||
| R | Lille OSC | - | RC Lens | 1:0 | ||
| H: 08.05.1981 | R: 19.05.1981 | Sieger: RC Lens | ||||
| H | AS Saint-Étienne | - | Montpellier Paillade SC | 2:1 | ||
| R | Montpellier Paillade SC | - | AS Saint-Étienne | 1:1 | ||
| H: 08.05.1981 | R: 19.05.1981 | Sieger: AS Saint-Étienne | ||||
| H | Girondins Bordeaux | - | RC Strasbourg | 1:5 | ||
| R | RC Strasbourg | - | Girondins Bordeaux | 4:0 | ||
| H: 08.05.1981 | R: 19.05.1981 | Sieger: RC Strasbourg | ||||
