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| H | AS Angoulême | - | Stade de Reims | 2:0 | ||
| R | Stade de Reims | - | AS Angoulême | 1:0 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: AS Angoulême | ||||
| H | FC Metz | - | AJ Auxerre | 2:2 | ||
| R | AJ Auxerre | - | FC Metz | 1:0 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: AJ Auxerre | ||||
| H | AS Monaco | - | Lille OSC | 4:0 | ||
| R | Lille OSC | - | AS Monaco | 2:0 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: AS Monaco | ||||
| H | RC Lens | - | Montpellier Paillade SC | 5:4 | ||
| R | Montpellier Paillade SC | - | RC Lens | 2:0 | ||
| H: 11.04.1980 | R: 21.04.1980 | Sieger: Montpellier Paillade SC | ||||
| H | US Orléans | - | RC Franc-Comtois de Besançon | 1:0 | ||
| R | RC Franc-Comtois de Besançon | - | US Orléans | 1:2 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: US Orléans | ||||
| H | Stade Rennais | - | Paris FC | 2:0 | ||
| R | Paris FC | - | Stade Rennais | 4:0 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: Paris FC | ||||
| H | AS Saint-Étienne | - | OGC Nice | 4:1 | ||
| R | OGC Nice | - | AS Saint-Étienne | 2:2 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: AS Saint-Étienne | ||||
| H | US Valenciennes-Anzin | - | FC Sochaux | 2:0 | ||
| R | FC Sochaux | - | US Valenciennes-Anzin | 3:0 | ||
| H: 11.04.1980 | R: 15.04.1980 | Sieger: FC Sochaux | ||||
