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| H | Feyenoord | - | AS Roma | 1:0 (0:0) | ||
| R | AS Roma | - | Feyenoord | 4:1 (0:0, 2:1) n.V. | ||
| H: 13.04.2023 18:45 | R: 20.04.2023 21:00 | Sieger: AS Roma | ||||
| H | Manchester United | - | Sevilla FC | 2:2 (2:0) | ||
| R | Sevilla FC | - | Manchester United | 3:0 (1:0) | ||
| H: 13.04.2023 21:00 | R: 20.04.2023 21:00 | Sieger: Sevilla FC | ||||
| H | Juventus | - | Sporting CP | 1:0 (0:0) | ||
| R | Sporting CP | - | Juventus | 1:1 (1:1) | ||
| H: 13.04.2023 21:00 | R: 20.04.2023 21:00 | Sieger: Juventus | ||||
| H | Bayer Leverkusen | - | Union Saint-Gilloise | 1:1 (0:0) | ||
| R | Union Saint-Gilloise | - | Bayer Leverkusen | 1:4 (0:2) | ||
| H: 13.04.2023 21:00 | R: 20.04.2023 21:00 | Sieger: Bayer Leverkusen | ||||
