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| 18.02.2022 | 21:00 | FC Cartagena | - | Real Valladolid | 2:3 (1:2) | |
| 19.02.2022 | 16:00 | Real Zaragoza | - | UD Las Palmas | 2:1 (1:0) | |
| 18:15 | CD Tenerife | - | UD Ibiza | 2:0 (2:0) | ||
| 18:15 | Girona FC | - | SD Eibar | 0:1 (0:1) | ||
| 21:00 | Real Sociedad B | - | Málaga CF | 2:0 (1:0) | ||
| 20.02.2022 | 14:00 | CF Fuenlabrada | - | AD Alcorcón | 2:2 (1:0) | |
| 16:00 | Burgos CF | - | Real Oviedo | 0:1 (0:0) | ||
| 18:15 | SD Huesca | - | CD Lugo | 1:0 (0:0) | ||
| 18:15 | Sporting Gijón | - | SD Ponferradina | 2:3 (0:2) | ||
| 21:00 | UD Almería | - | CD Mirandés | 2:1 (0:0) | ||
| 21.02.2022 | 21:00 | SD Amorebieta | - | CD Leganés | 1:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 28 | 16 | 8 | 4 | 41:28 | 13 | 56 |
| 2 |
|
UD Almería | 28 | 17 | 4 | 7 | 44:22 | 22 | 55 |
| 3 |
|
CD Tenerife | 28 | 15 | 7 | 6 | 39:19 | 20 | 52 |
| 4 |
|
Real Valladolid | 28 | 15 | 7 | 6 | 41:28 | 13 | 52 |
| 5 |
|
SD Ponferradina | 28 | 13 | 8 | 7 | 37:30 | 7 | 47 |
| 6 |
|
Girona FC | 28 | 12 | 6 | 10 | 38:31 | 7 | 42 |
| 7 |
|
Real Oviedo | 28 | 9 | 14 | 5 | 33:28 | 5 | 41 |
| 8 |
|
UD Las Palmas | 28 | 10 | 9 | 9 | 35:34 | 1 | 39 |
| 9 |
|
FC Cartagena | 28 | 12 | 3 | 13 | 36:39 | -3 | 39 |
| 10 |
|
UD Ibiza | 28 | 9 | 11 | 8 | 36:33 | 3 | 38 |
| 11 |
|
Burgos CF | 28 | 11 | 5 | 12 | 32:27 | 5 | 38 |
| 12 |
|
SD Huesca | 28 | 9 | 10 | 9 | 35:28 | 7 | 37 |
| 13 |
|
CD Lugo | 28 | 7 | 15 | 6 | 33:31 | 2 | 36 |
| 14 |
|
CD Leganés | 28 | 9 | 9 | 10 | 31:32 | -1 | 36 |
| 15 |
|
Sporting Gijón | 28 | 9 | 8 | 11 | 31:33 | -2 | 35 |
| 16 |
|
Real Zaragoza | 28 | 6 | 15 | 7 | 23:29 | -6 | 33 |
| 17 |
|
Málaga CF | 28 | 8 | 8 | 12 | 24:42 | -18 | 32 |
| 18 |
|
CD Mirandés | 28 | 8 | 6 | 14 | 35:45 | -10 | 30 |
| 19 |
|
SD Amorebieta | 28 | 4 | 14 | 10 | 32:41 | -9 | 26 |
| 20 |
|
CF Fuenlabrada | 28 | 4 | 14 | 10 | 22:33 | -11 | 26 |
| 21 |
|
Real Sociedad B | 28 | 5 | 8 | 15 | 25:37 | -12 | 23 |
| 22 |
|
AD Alcorcón | 28 | 2 | 7 | 19 | 21:54 | -33 | 13 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
