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| H | UANL Tigres | - | Club León | 2:1 (2:1) | ||
| R | Club León | - | UANL Tigres | 3:1 (2:0) | ||
| H: 26.04.2023 04:00 | R: 04.05.2023 04:00 | Sieger: Club León | ||||
| H | Philadelphia Union | - | Los Angeles FC | 1:1 (0:0) | ||
| R | Los Angeles FC | - | Philadelphia Union | 3:0 (1:0) | ||
| H: 27.04.2023 03:00 | R: 03.05.2023 04:00 | Sieger: Los Angeles FC | ||||
