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| H | Unión Magdalena | - | Tigres FC | 1:0 (1:0) | ||
| R | Tigres FC | - | Unión Magdalena | 4:2 (1:0, 1:0) i.E. | ||
| H: 05.04.2023 22:30 | R: 02.05.2023 22:00 | Sieger: Tigres FC | ||||
| H | Deportivo Cali | - | Jaguares de Córdoba | 1:0 (1:0) | ||
| R | Jaguares de Córdoba | - | Deportivo Cali | 3:5 (0:0, 1:0, 1:0) i.E. | ||
| H: 06.04.2023 02:00 | R: 04.05.2023 22:45 | Sieger: Deportivo Cali | ||||
| H | Orsomarso SC | - | Alianza Petrolera | 1:1 (0:0) | ||
| R | Alianza Petrolera | - | Orsomarso SC | 3:1 (0:0) | ||
| H: 06.04.2023 21:50 | R: 03.05.2023 02:40 | Sieger: Alianza Petrolera | ||||
| H | Real Cartagena | - | Cúcuta Deportivo | 0:1 (0:1) | ||
| R | Cúcuta Deportivo | - | Real Cartagena | 0:0 (0:0) | ||
| H: 13.04.2023 01:00 | R: 03.05.2023 22:45 | Sieger: Cúcuta Deportivo | ||||
