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| H | Orsomarso SC | - | Atlético Huila | 1:0 (1:0) | ||
| R | Atlético Huila | - | Orsomarso SC | 0:0 (0:0) | ||
| H: 14.02.2023 22:00 | R: 22.02.2023 00:00 | Sieger: Orsomarso SC | ||||
| H | Valledupar FC | - | Jaguares de Córdoba | 0:2 (0:0) | ||
| R | Jaguares de Córdoba | - | Valledupar FC | 1:0 (1:0) | ||
| H: 15.02.2023 00:00 | R: 22.02.2023 23:30 | Sieger: Jaguares de Córdoba | ||||
| H | Atlético FC | - | Envigado FC | 2:0 (1:0) | ||
| R | Envigado FC | - | Atlético FC | 4:2 (1:0, 2:0) i.E. | ||
| H: 15.02.2023 21:00 | R: 22.02.2023 23:30 | Sieger: Envigado FC | ||||
| H | Boyacá Chicó | - | Real Cartagena | 1:1 (1:1) | ||
| R | Real Cartagena | - | Boyacá Chicó | 8:7 (0:0, 0:0) i.E. | ||
| H: 15.02.2023 23:15 | R: 23.02.2023 23:30 | Sieger: Real Cartagena | ||||
| H | Alianza Petrolera | - | Real Santander | 4:1 (2:0) | ||
| R | Real Santander | - | Alianza Petrolera | 1:0 (0:0) | ||
| H: 16.02.2023 00:00 | R: 23.02.2023 21:00 | Sieger: Alianza Petrolera | ||||
| H | Cúcuta Deportivo | - | Once Caldas | 3:1 (2:1) | ||
| R | Once Caldas | - | Cúcuta Deportivo | 1:0 (0:0) | ||
| H: 16.02.2023 21:30 | R: 23.02.2023 02:00 | Sieger: Cúcuta Deportivo | ||||
| H | Boca Juniors de Cali | - | Unión Magdalena | 0:1 (0:0) | ||
| R | Unión Magdalena | - | Boca Juniors de Cali | 3:0 (1:0) | ||
| H: 16.02.2023 22:00 | R: 22.02.2023 22:00 | Sieger: Unión Magdalena | ||||
| H | Barranquilla FC | - | Deportivo Cali | 3:3 (1:2) | ||
| R | Deportivo Cali | - | Barranquilla FC | 6:0 (3:0) | ||
| H: 16.02.2023 23:30 | R: 24.02.2023 02:00 | Sieger: Deportivo Cali | ||||
