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| 24.01.2022 | 19:30 | Sporting Charleroi II | - | Sint-Truidense VV II | 1:4 (0:2) | |
| 19:30 | Standard Liège II | - | RSC Anderlecht II | 0:3 | ||
| 19:30 | Royal Antwerp FC II | - | KRC Genk II | 1:4 | ||
| 19:30 | Cercle Brugge II | - | KAA Gent II | 0:1 (0:0) | ||
| 20:00 | KV Mechelen II | - | Club NXT | 1:0 (0:0) | ||
| 20:00 | Oud-Heverlee Leuven II | - | SV Zulte Waregem II | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk II | 13 | 11 | 2 | 0 | 40:9 | 31 | 35 |
| 2 |
|
RSC Anderlecht II | 13 | 10 | 2 | 1 | 31:9 | 22 | 32 |
| 3 |
|
Standard Liège II | 13 | 8 | 1 | 4 | 22:18 | 4 | 25 |
| 4 |
|
Club NXT | 13 | 7 | 2 | 4 | 32:10 | 22 | 23 |
| 5 |
|
KAA Gent II | 13 | 6 | 4 | 3 | 24:18 | 6 | 22 |
| 6 |
|
Oud-Heverlee Leuven II | 13 | 5 | 2 | 6 | 19:20 | -1 | 17 |
| 7 |
|
Sint-Truidense VV II | 13 | 4 | 3 | 6 | 15:19 | -4 | 15 |
| 8 |
|
Sporting Charleroi II | 13 | 4 | 2 | 7 | 12:25 | -13 | 14 |
| 9 |
|
SV Zulte Waregem II | 13 | 4 | 1 | 8 | 21:32 | -11 | 13 |
| 10 |
|
Cercle Brugge II | 13 | 2 | 3 | 8 | 16:26 | -10 | 9 |
| 11 |
|
Royal Antwerp FC II | 13 | 2 | 2 | 9 | 12:30 | -18 | 8 |
| 12 |
|
KV Mechelen II | 13 | 2 | 2 | 9 | 10:38 | -28 | 8 |
| Abstieg |
