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| H | Flamurtari Vlorë | - | FK Vllaznia | 1:2 | ||
| R | FK Vllaznia | - | Flamurtari Vlorë | 1:0 | ||
| H: 26.01.2022 13:45 | R: 10.02.2022 13:45 | Sieger: FK Vllaznia | ||||
| H | Egnatia Rrogozhine | - | KF Laçi | 1:1 | ||
| R | KF Laçi | - | Egnatia Rrogozhine | 3:2 i.E. | ||
| H: 26.01.2022 13:45 | R: 10.02.2022 13:45 | Sieger: KF Laçi | ||||
| H | KF Skënderbeu | - | KF Teuta Durrës | 0:1 | ||
| R | KF Teuta Durrës | - | KF Skënderbeu | 1:0 (1:0) | ||
| H: 27.01.2022 14:25 | R: 09.02.2022 16:45 | Sieger: KF Teuta Durrës | ||||
| H | Dinamo Tiranë | - | FK Partizani | 1:1 | ||
| R | FK Partizani | - | Dinamo Tiranë | 1:0 | ||
| H: 27.01.2022 16:45 | R: 10.02.2022 18:00 | Sieger: FK Partizani | ||||
