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| 23.10.2021 | 11:00 | SC Freiburg | - | 1. FC Nürnberg | 0:4 (0:3) | |
| 11:00 | 1. FC Kaiserslautern | - | FC Ingolstadt 04 | 2:0 (1:0) | ||
| 12:00 | Kickers Offenbach | - | SpVgg Greuther Fürth | 2:3 (1:0) | ||
| 12:00 | SV Darmstadt 98 | - | Karlsruher SC | 1:2 (0:2) | ||
| 24.10.2021 | 10:30 | 1. FC Heidenheim 1846 | - | 1. FSV Mainz 05 | 0:3 (0:1) | |
| 11:00 | FC Augsburg | - | Eintracht Frankfurt | 3:3 (2:1) | ||
| 11:00 | Bayern München | - | 1899 Hoffenheim | 1:1 (0:0) | ||
| 11:00 | SSV Ulm 1846 | - | Hessen Kassel | 4:0 (1:0) | ||
| 13:00 | Stuttgarter Kickers | - | FC-Astoria Walldorf | 1:1 (0:0) | ||
| 13:00 | 1. FC Saarbrücken | - | VfB Stuttgart | 0:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 8 | 7 | 0 | 1 | 22:9 | 13 | 21 |
| 2 |
|
VfB Stuttgart | 8 | 6 | 1 | 1 | 22:7 | 15 | 19 |
| 3 |
|
1899 Hoffenheim | 8 | 5 | 2 | 1 | 33:16 | 17 | 17 |
| 4 |
|
Eintracht Frankfurt | 8 | 4 | 2 | 2 | 24:12 | 12 | 14 |
| 5 |
|
FC Augsburg | 7 | 4 | 2 | 1 | 13:9 | 4 | 14 |
| 6 |
|
SpVgg Unterhaching | 7 | 4 | 2 | 1 | 12:8 | 4 | 14 |
| 7 |
|
1. FSV Mainz 05 | 8 | 4 | 1 | 3 | 24:12 | 12 | 13 |
| 8 |
|
1. FC Heidenheim 1846 | 8 | 4 | 1 | 3 | 15:11 | 4 | 13 |
| 9 |
|
SV Darmstadt 98 | 8 | 3 | 2 | 3 | 8:15 | -7 | 11 |
| 10 |
|
Bayern München | 7 | 3 | 1 | 3 | 15:12 | 3 | 10 |
| 11 |
|
Karlsruher SC | 7 | 2 | 4 | 1 | 10:8 | 2 | 10 |
| 12 |
|
SC Freiburg | 8 | 3 | 1 | 4 | 18:21 | -3 | 10 |
| 13 |
|
SSV Ulm 1846 | 7 | 3 | 0 | 4 | 11:12 | -1 | 9 |
| 14 |
|
SpVgg Greuther Fürth | 8 | 2 | 3 | 3 | 9:13 | -4 | 9 |
| 15 |
|
1. FC Kaiserslautern | 8 | 3 | 0 | 5 | 17:27 | -10 | 9 |
| 16 |
|
Stuttgarter Kickers | 8 | 2 | 2 | 4 | 11:21 | -10 | 8 |
| 17 |
|
FC Ingolstadt 04 | 7 | 2 | 1 | 4 | 12:14 | -2 | 7 |
| 18 |
|
FC-Astoria Walldorf | 7 | 1 | 3 | 3 | 10:17 | -7 | 6 |
| 19 |
|
Kickers Offenbach | 8 | 2 | 0 | 6 | 10:22 | -12 | 6 |
| 20 |
|
1. FC Saarbrücken | 7 | 1 | 0 | 6 | 5:16 | -11 | 3 |
| 21 |
|
Hessen Kassel | 8 | 1 | 0 | 7 | 4:23 | -19 | 3 |
| Playoffs | |
| Abstieg |
