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| 20.11.2021 | 11:00 | SC Freiburg | - | 1. FSV Mainz 05 | 1:3 (0:3) | |
| 11:00 | SV Darmstadt 98 | - | FC Ingolstadt 04 | 0:0 (0:0) | ||
| 12:30 | 1. FC Saarbrücken | - | 1899 Hoffenheim | 1:3 (0:1) | ||
| 13:00 | Kickers Offenbach | - | Karlsruher SC | 5:1 (4:0) | ||
| 13:00 | Bayern München | - | 1. FC Nürnberg | 1:2 (1:1) | ||
| 13:00 | SSV Ulm 1846 | - | SpVgg Greuther Fürth | 1:4 (0:2) | ||
| 14:00 | 1. FC Heidenheim 1846 | - | FC-Astoria Walldorf | 0:3 (0:2) | ||
| 15:00 | VfB Stuttgart | - | Eintracht Frankfurt | 3:0 (1:0) | ||
| 21.11.2021 | 13:00 | Stuttgarter Kickers | - | SpVgg Unterhaching | 1:2 (1:0) | |
| 14:00 | FC Augsburg | - | Hessen Kassel | 8:1 (5:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 10 | 9 | 0 | 1 | 26:11 | 15 | 27 |
| 2 |
|
VfB Stuttgart | 9 | 7 | 1 | 1 | 25:7 | 18 | 22 |
| 3 |
|
1899 Hoffenheim | 10 | 6 | 2 | 2 | 38:21 | 17 | 20 |
| 4 |
|
FC Augsburg | 9 | 6 | 2 | 1 | 25:12 | 13 | 20 |
| 5 |
|
SpVgg Unterhaching | 9 | 6 | 2 | 1 | 17:9 | 8 | 20 |
| 6 |
|
1. FSV Mainz 05 | 10 | 6 | 1 | 3 | 31:13 | 18 | 19 |
| 7 |
|
Eintracht Frankfurt | 10 | 5 | 2 | 3 | 27:15 | 12 | 17 |
| 8 |
|
1. FC Heidenheim 1846 | 10 | 4 | 2 | 4 | 17:16 | 1 | 14 |
| 9 |
|
Bayern München | 9 | 4 | 1 | 4 | 23:14 | 9 | 13 |
| 10 |
|
SC Freiburg | 10 | 4 | 1 | 5 | 20:24 | -4 | 13 |
| 11 |
|
SV Darmstadt 98 | 10 | 3 | 4 | 3 | 9:16 | -7 | 13 |
| 12 |
|
SpVgg Greuther Fürth | 10 | 3 | 3 | 4 | 13:15 | -2 | 12 |
| 13 |
|
FC Ingolstadt 04 | 9 | 3 | 2 | 4 | 16:15 | 1 | 11 |
| 14 |
|
Karlsruher SC | 9 | 2 | 5 | 2 | 13:15 | -2 | 11 |
| 15 |
|
FC-Astoria Walldorf | 9 | 2 | 4 | 3 | 14:18 | -4 | 10 |
| 16 |
|
SSV Ulm 1846 | 9 | 3 | 0 | 6 | 13:18 | -5 | 9 |
| 17 |
|
Kickers Offenbach | 10 | 3 | 0 | 7 | 15:27 | -12 | 9 |
| 18 |
|
1. FC Kaiserslautern | 9 | 3 | 0 | 6 | 17:30 | -13 | 9 |
| 19 |
|
Stuttgarter Kickers | 10 | 2 | 2 | 6 | 13:27 | -14 | 8 |
| 20 |
|
1. FC Saarbrücken | 9 | 1 | 0 | 8 | 6:22 | -16 | 3 |
| 21 |
|
Hessen Kassel | 10 | 1 | 0 | 9 | 5:38 | -33 | 3 |
| Playoffs | |
| Abstieg |
