| 1. Spieltag | 28.08.2021 | Twente/Heracles [U21] | - | Almere City FC [U21] | 1:2 |  |
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| 5. Spieltag | 02.10.2021 | Twente/Heracles [U21] | - | ADO Den Haag [U21] | 0:0 | ||||
| 6. Spieltag | 16.10.2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 7. Spieltag | 23.10.2021 | sc Heerenveen [U21] | - | Twente/Heracles [U21] | 0:3 | ||||
| 8. Spieltag | 30.10.2021 | ADO Den Haag [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 10. Spieltag | 20.11.2021 | NAC Breda [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 11. Spieltag | 04.12.2021 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 1:1 | ||||
| 13. Spieltag | 26.02.2022 | Twente/Heracles [U21] | - | sc Heerenveen [U21] | 1:1 |
Bulgarien