| 1. Spieltag | 28.08.2021 | Twente/Heracles [U21] | - | Almere City FC [U21] | 1:2 |  |
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| 2. Spieltag | 11.09.2021 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 2:1 | ||||
| 3. Spieltag | 18.09.2021 | Twente/Heracles [U21] | - | NAC Breda [U21] | 5:2 | ||||
| 4. Spieltag | 25.09.2021 | Feyenoord [U21] | - | Twente/Heracles [U21] | 2:0 | ||||
| 5. Spieltag | 02.10.2021 | Twente/Heracles [U21] | - | ADO Den Haag [U21] | 0:0 | ||||
| 6. Spieltag | 16.10.2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 |  |
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| 7. Spieltag | 23.10.2021 | sc Heerenveen [U21] | - | Twente/Heracles [U21] | 0:3 | ||||
| 8. Spieltag | 30.10.2021 | ADO Den Haag [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 9. Spieltag | 06.11.2021 | Twente/Heracles [U21] | - | Feyenoord [U21] | 0:3 | ||||
| 10. Spieltag | 20.11.2021 | NAC Breda [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 11. Spieltag | 04.12.2021 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 1:1 | ||||
| 14. Spieltag | 18.12.2021 | FC Groningen [U21] | - | Twente/Heracles [U21] | 6:1 |
Niederlande