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| 07.03.2018 | 02:00 | Cafetaleros de Tapachula | - | Monarcas Morelia | 4:2 (1:2) | |
| 02:00 | Club Necaxa | - | Atlas Guadalajara | 2:1 (0:0) | ||
| 04:05 | Deportivo Toluca | - | Alebrijes de Oaxaca | 2:0 (1:0) | ||
| 04:05 | TM Fútbol Club | - | Santos Laguna | 0:1 (0:1) | ||
| 08.03.2018 | 02:00 | CF Monterrey | - | Gallos Blancos | 2:3 (1:1, 1:1) i.E. | |
| 02:00 | Atlético Zacatepec | - | CF Pachuca | 5:3 (1:0, 1:1) i.E. | ||
| 04:05 | Pumas UNAM | - | Lobos BUAP | 3:0 (0:0) | ||
| 04:06 | Club León | - | Club Celaya | 4:1 (3:0) |
