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| 20.04.2021 | 20:45 | Hellas Verona | - | ACF Fiorentina | 1:2 (0:1) | |
| 21.04.2021 | 18:30 | AC Milan | - | Sassuolo Calcio | 1:2 (1:0) | |
| 20:45 | Genoa CFC | - | Benevento Calcio | 2:2 (2:2) | ||
| 20:45 | Udinese Calcio | - | Cagliari Calcio | 0:1 (0:0) | ||
| 20:45 | Spezia Calcio | - | Inter | 1:1 (1:1) | ||
| 20:45 | Juventus | - | Parma Calcio 1913 | 3:1 (1:1) | ||
| 20:45 | FC Crotone | - | Sampdoria | 0:1 (0:0) | ||
| 20:45 | Bologna FC | - | Torino FC | 1:1 (1:0) | ||
| 22.04.2021 | 18:30 | AS Roma | - | Atalanta | 1:1 (0:1) | |
| 20:45 | SSC Napoli | - | Lazio Roma | 5:2 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Inter | 32 | 23 | 7 | 2 | 71:29 | 42 | 76 |
| 2 |
|
AC Milan | 32 | 20 | 6 | 6 | 60:38 | 22 | 66 |
| 3 |
|
Juventus | 32 | 19 | 8 | 5 | 64:29 | 35 | 65 |
| 4 |
|
Atalanta | 32 | 19 | 8 | 5 | 73:39 | 34 | 65 |
| 5 |
|
SSC Napoli | 32 | 20 | 3 | 9 | 71:37 | 34 | 63 |
| 6 |
|
Lazio Roma | 32 | 18 | 5 | 9 | 53:46 | 7 | 59 |
| 7 |
|
AS Roma | 32 | 16 | 7 | 9 | 56:48 | 8 | 55 |
| 8 |
|
Sassuolo Calcio | 32 | 13 | 10 | 9 | 54:50 | 4 | 49 |
| 9 |
|
Sampdoria | 32 | 12 | 6 | 14 | 43:46 | -3 | 42 |
| 10 |
|
Hellas Verona | 32 | 11 | 8 | 13 | 40:40 | 0 | 41 |
| 11 |
|
Bologna FC | 32 | 10 | 8 | 14 | 44:48 | -4 | 38 |
| 12 |
|
Udinese Calcio | 32 | 9 | 9 | 14 | 34:42 | -8 | 36 |
| 13 |
|
ACF Fiorentina | 32 | 8 | 9 | 15 | 41:53 | -12 | 33 |
| 14 |
|
Genoa CFC | 32 | 7 | 12 | 13 | 35:48 | -13 | 33 |
| 15 |
|
Spezia Calcio | 32 | 8 | 9 | 15 | 42:60 | -18 | 33 |
| 16 |
|
Torino FC | 32 | 6 | 14 | 12 | 46:54 | -8 | 32 |
| 17 |
|
Benevento Calcio | 32 | 7 | 10 | 15 | 35:62 | -27 | 31 |
| 18 |
|
Cagliari Calcio | 32 | 7 | 7 | 18 | 36:54 | -18 | 28 |
| 19 |
|
Parma Calcio 1913 | 32 | 3 | 11 | 18 | 33:66 | -33 | 20 |
| 20 |
|
FC Crotone | 32 | 4 | 3 | 25 | 38:80 | -42 | 15 |
| Champions League | |
| Europa League | |
| Europa Conference League Quali. | |
| Abstieg |
