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| H | CF América | - | Tauro FC | 4:0 (1:0) | ||
| R | Tauro FC | - | CF América | 1:3 (0:2) | ||
| H: 07.03.2018 02:00 | R: 15.03.2018 01:00 | Sieger: CF América | ||||
| H | Club Tijuana | - | New York RB | 0:2 (0:1) | ||
| R | New York RB | - | Club Tijuana | 3:1 (1:1) | ||
| H: 07.03.2018 04:00 | R: 14.03.2018 01:00 | Sieger: New York RB | ||||
| H | Toronto FC | - | UANL Tigres | 2:1 (0:0) | ||
| R | UANL Tigres | - | Toronto FC | 3:2 (0:0) | ||
| H: 08.03.2018 02:00 | R: 14.03.2018 03:00 | Sieger: Toronto FC | ||||
| H | Seattle Sounders | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| R | Deportivo Guadalajara | - | Seattle Sounders | 3:0 (0:0) | ||
| H: 08.03.2018 04:00 | R: 15.03.2018 03:00 | Sieger: Deportivo Guadalajara | ||||
