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| H | Universidad de Chile | - | Cobreloa | 2:1 (1:0) | ||
| R | Cobreloa | - | Universidad de Chile | 2:3 (0:0) | ||
| H: 07.07.2018 23:30 | R: 14.07.2018 21:30 | Sieger: Universidad de Chile | ||||
| H | Deportes Valdivia | - | Barnechea | 0:1 (0:0) | ||
| R | Barnechea | - | Deportes Valdivia | 5:4 (0:0, 1:2) i.E. | ||
| H: 08.07.2018 18:30 | R: 14.07.2018 02:00 | Sieger: Barnechea | ||||
| H | Cobresal | - | Palestino | 1:1 (1:1) | ||
| R | Palestino | - | Cobresal | 1:0 (0:0) | ||
| H: 08.07.2018 21:30 | R: 15.07.2018 00:00 | Sieger: Palestino | ||||
| H | Audax Italiano | - | Huachipato | 2:1 (2:1) | ||
| R | Huachipato | - | Audax Italiano | 1:2 (0:0) | ||
| H: 09.07.2018 00:00 | R: 14.07.2018 18:30 | Sieger: Audax Italiano | ||||
